Biotech veterans launch Corsera, a new heart disease startup with lofty goals

Allison DeAngelis is the East Coast biotech and venture capital reporter at STAT, reporting where scientific ideas and money meet. She is also co-host of the weekly biotech podcast, The Readout Loud. You can reach Allison on Signal at AllisonDeAngelis.01.

Biotech veterans John Maraganore and Clive Meanwell have had a hand in multiple paradigm-shifting medicines over the last three decades. But on Tuesday, the duo launched a new venture they say may be their most important work to date.

The venture, Corsera Health, is a small company with a big goal: Create a world without cardiovascular disease. Corsera is developing an AI tool called Klotho Health that will predict a person’s likelihood of developing cardiovascular disease. In tandem with that effort, Corsera is working on an RNAi drug that targets PCSK9 — one of the known drivers of heart disease — and angiotensinogen, which influences blood pressure. 

The company plans to start a clinical trial of that drug by the end of the year.

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